Effect of Transcranial Low-Level Light Therapy vs Sham Therapy Among Patients With Moderate Traumatic Brain Injury: A Randomized Clinical Trial

Abstract and Figures

Importance: Preclinical studies have shown that transcranial near-infrared low-level light therapy (LLLT) administered after traumatic brain injury (TBI) confers a neuroprotective response.

Objectives: To assess the feasibility and safety of LLLT administered acutely after a moderate TBI and the neuroreactivity to LLLT through quantitative magnetic resonance imaging metrics and neurocognitive assessment.

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Light Therapy Saves Former BYU Linebacker From Suicide

For six weeks he reported to the V.A. alongside returning vets from Afghanistan and Iraq. The treatment was painless. In a process called photobiomodulation, each subject was hooked up to a machine that sent what is called “near infrared light” to various parts of the brain.“It’s groundbreaking, there’s no other word to describe it,” he says. “It just seems to reset the brain. The only side effect is I’m stronger and in better shape than I’ve ever been.”

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Effects of Home Photobiomodulation Treatments on Cognitive & Behavioral Function, Cerebral Perfusion and Resting-State Functional Connectivity in Patients with Dementia

This study sought to replicate and build upon a previously published cases series report describing improved cognitive function in five patients with mild to moderate dementia after 12 weeks of transcranial and intranasal near-infrared (NIR) PBM therapy.

In collaboration with the University of California San Francisco using the Neuro Gamma device on neural connectivity and cerebral blood flow.


Pulsed Near Infrared Transcranial and Intranasal Photobiomodulation Significantly Modulates Neural Oscillations

Transcranial PBM (tPBM), targeting delivery of light energy to the brain, is associated with increased cerebral blood flow, oxygen availability and consumption, adenoside triphophosphate (ATP) production, and improved mitochondrial activity4. More recently, tPBM has demonstrated its value as a treatment for neurological5–10 and neurodegenerative conditions, including Alzheimer’s disease11,12. Thus, tPBM is a form of non-invasive brain stimulation (NIBS). However, compared to the more established forms of NIBS, such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), the concept of the brain being responsive to light stimulation is unfamiliar to many. In recent years, research on the potential efficacy of tPBM has gained momentum13. Research on the effect of PBM on brain cell recovery has shown that, under laboratory conditions, damaged neurons can regrow their neurites with direct exposure to visible red low level lasers14. In an animal study, PBM has been found capable of promoting neurogenesis after ischemic stroke through the proliferation and differentiation of internal neuroprogenitor cells.