PBM2021 will focus on PBM becoming a mainstream medical procedure. Institutions such as NICE in the UK and medical insurance companies in the US now recognize PBM as “medically necessary”. Regulatory gatekeepers, reimbursement experts, and policy officials will be invited to explain the roadmap to medical acceptance. Last year, 627 academic papers were published on PBM bringing the total to over 7,000 in the last 30 years. This conference will be about leveraging this body of science to make PBM more readily available.